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The first North American gamma knife for stereotactic radiosurgery of brain tumors and arteriovenous malformations entered the therapeutic armamentarium at the University of Pittsburg(Pa)on August 14,1987.In this article,we report our initial testing and subsequent experience with this technique.In the first 16 months of operation,207 patients were treated (113 had arteriovenous malformations,78 had extra-axial skull base neoplasms,9 had glial neoplasms,and 7 had metastatic tumors).The patients' lesions either were considered previously as"inoperable"or were residual lesions after attempted surgical resection,or the radiosurgery was performed after the patient declined surgical excision.Gamma radiosurgery was associated with no surgical mortality and no significant early morbidity,and the results were encouraging during the minimum follow-up period of 6 months.Compared with treatment by conventional intracranial surgery(craniotomy),both the average length of stay and hospital changes for radiosurgery were significantly lower.Our initial experience further suggests that stereotactic radiosurgery using the gamma knife is a therapeutically effective and economically sound alternative to microneurosurgical removal of selected intracranial tumors and vascular malformations. |
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acoustic neurinoma
amyloid angiopathy,hereditary cystatin C
gamma knife therapy
malformation,vascular
malformation,vascular,treatment of
neoplasm,metastatic to CNS
neoplasm,metastatic to CNS-treatment of
neoplasm,primary intracranial
neoplasm,primary intracranial-treatment of
neoplasm,primary of CNS
neoplasm,primary of CNS-treatment of
radiation therapy,CNS treatment and complications with
radiation therapy,stereotactic
treatment of neurologic disorder
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